PECAM-1: regulator of endothelial junctional integrity

p120: the guardian of endothelial junctional integrity.

THE ENDOTHELIUM, composed of the endothelial monolayer and underlying matrix, constitutes the major regulatory barrier of the vascular system by finely controlling the fluxes of macromolecules across the vessel walls. An increase in the permeability of the endothelial monolayer in the lung has been established as the major cause of acute lung injury (6, 12). It has become progressively clear th...

PECAM-1: a multifaceted regulator of megakaryocytopoiesis.

PECAM-1 (CD31) knockout (KO) mice exhibit excessive megakaryocytopoiesis accompanied by increased numbers of megakaryocytes associated with the stromal niche rather than the vascular niche. During earlier stages of megakaryocytopoiesis in KO marrow, an expanded Lin(-)Sca-1(+) c-kit(+) hematopoietic stem cell (HSC) population and increased quiescent Lin(-) progenitor pool were identified. During...

Editorial Focus p120: the guardian of endothelial junctional integrity

THE ENDOTHELIUM, composed of the endothelial monolayer and underlying matrix, constitutes the major regulatory barrier of the vascular system by finely controlling the fluxes of macromolecules across the vessel walls. An increase in the permeability of the endothelial monolayer in the lung has been established as the major cause of acute lung injury (6, 12). It has become progressively clear th...

Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.

Platelet/endothelial cell adhesion molecule-1 (PECAM-1; CD31), a member of the Ig superfamily, is expressed strongly at endothelial cell-cell junctions, on platelets, and on most leukocytes. CD31 has been postulated to play a role in vasculogenesis and angiogenesis, and has been implicated as a key mediator of the transendothelial migration of leukocytes. To further define the physiologic role ...

Foxc1 regulates Pecam-1 Expression in embryonic Endothelial Progenitor Cells